Your genes and drugs addiction.

Over the last decade, the prevalence of opioid addiction has increased to epidemic levels, but unfortunately, therapeutic interventions for the treatment of addiction remain limited. We need to better understand the triggers for the development of addiction in order to develop more targeted prevention and treatments. One of the key questions that researchers in the … Read more

The Benefits of Genetic Addiction Risk Score (GARS™) Testing in Substance Use Disorder

Following 25 years of extensive research by many scientists worldwide, a panel of ten reward gene risk variants, called the Genetic Addiction Risk Score (GARS), has been developed. In unpublished work, when GARS was compared to the Addiction Severity Index (ASI), which has been used in many clinical settings, GARS significantly predicted the severity of … Read more

Regulatory and Legislative Disparities With Cannabis Present Challenges to P&T Committees and Health Care Providers

By – Rita Marcoux, RPh, MBA; Lauren Holmes, PharmD, MBA, MPH; and F. Randy Vogenberg, BSc Pharm, PhD INTRODUCTION Over the past several years, the legal status of cannabis has been determined by regulatory changes affecting its use, as well as the use of cannabidiol (CBD). Prior to 2018, CBD, along with all forms of marijuana, was … Read more

Beyond Medical Cannabis: Considerations for Updates to Hospital Policies and Procedures

By – James O’Donnell, PharmD, MS, FCP, and F. Randy Vogenberg, BSc Pharm, PhD INTRODUCTION Cannabis (marijuana) is classified as a schedule-I controlled substance, currently not accepted for medical use and with a high potential for abuse. As stated in a previous P&T article, although marijuana remains illegal at the federal level, 33 states have legalized its … Read more

Psych side effects THC

Researchers at Western University have shown for the first time the molecular mechanisms at work that cause cannabidiol, or CBD, to block the psychiatric side-effects caused by tetrahydrocannabinol (THC), the main psychoactive chemical in cannabis. Read more on –

The smart way to change our marijuana laws

(CNN)As a career prosecutor and former attorney general of California, I saw firsthand how counterproductive marijuana laws exacerbated the problem of mass incarceration in my state and in our country — leading to the disproportionate criminalization of black and brown people in particular. Read more on

CBD offsets psych side effects THC

Summary: CBD blocks the ability of THC to overstimulate the ERK pathway in the hippocampus, preventing negative side effects associated with cannabis use. Source: University of Western Ontario Researchers at Western University have shown for the first time the molecular mechanisms at work that cause cannabidiol, or CBD, to block the psychiatric side-effects caused by tetrahydrocannabinol (THC), … Read more

Vaping illnesses: The difference between black market and medical marijuana dispensaries.

The state of Michigan has not gotten any reports of adverse effects from THC-infused vapes that have been sold by medical marijuana dispensaries. The distinction between black-market vapes and those sold at medical marijuana dispensaries is important. The marijuana concentrate in the vapes sold at licensed pot shops has to go through testing both before and after … Read more