“What goes up must come down,” and “For every action there is an equal and opposite reaction” are two laws of physics pronounced by Isaac Newton. Robert Louis Stevenson’s Dr. Jekyll and Mr. Hyde dramatized how these laws also hold sway in the world of psychopharmacology.
The main psychoactive ingredient in cannabis, THC, activates cannabinoid (CB1) receptors naturally found in the brain. This activation is stronger and longer than activation by our natural cannabinoid chemistry. The neurotransmitters anandamide and 2-AG produced by the brain to stimulate these receptors are subtle and brief. The brain’s system of THC-like transmitters and their unique receptors functions to regulate and balance the rest of brain chemistry.
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